基于聚集诱导发光(AIE)生物荧光材料的开发及其在生物医学/航天生物医学领域的应用

《分子探针与医学影像》

1. 北理青年教师学术启动计划，2021.01-2023.12，主持

2. 国家自然科学基金，青年项目，2022.01-2024.12，主持

[1] Ruoyao Zhang,* Chen Zhang, Chao Chen, Minggang Tian, Joe H. C. Chau, Zhao Li, Yuanzhan Yang, Xiaoqiong Li, and Ben Zhong Tang*. Autophagy-Activated Self-reporting Photosensitizer Promoting Cell Mortality in Cancer Starvation Therapy. Adv. Sci. 2023, 2301295.

[2] Chen Zhang, Ruoyao Zhang,* Chaohui Liang, Yifan Deng, Zhao Li, Yulin Deng,* Ben Zhong Tang*. Charge-elimination strategy for constructing RNA-selective fluorescent probe undisturbed by mitochondria. Biomaterials 2022, 291, 121915.

[3] Ruoyao Zhang, Xiaolin Huang,* Chao Chen, Ryan T.K. Kwok, Jacky W.Y. Lam, Ben Zhong Tang.* AIEgen for cancer discrimination. Materials Science & Engineering R. 2021, 146, 100649.

[4] Ruoyao Zhang, Guangle Niu, Zhiyang Liu, Joe H.C. Chau, Huifang Su, Michelle M.S. Lee, Yuan Gu, Ryan T.K. Kwok, Jacky W.Y. Lam, Ben Zhong Tang*. Single AIEgen for multiple tasks: Imaging of dual organelles and evaluation of cell viability. Biomaterials, 2020, 242, 119924.

[5] Ruoyao Zhang, Guangle Niu, Qing Lu, Xiaolin Huang, Joe H. C. Chau, Ryan T. K. Kwok, Xiaoqiang Yu, Min-Hui Li*, Jacky W. Y. Lam*, and Ben Zhong Tang*. Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens. Chem. Sci. 2020, 11, 7676-7684.

[6] Ruoyao Zhang, ‡ Guangle Niu, ‡ Xuechen Li, Lifang Guo, Huamiao Zhang, Rui Yang, Yuncong Chen, Xiaoqiang Yu*, and Ben Zhong Tang*. Reaction-free and MMP-independent fluorescent probes for long-term mitochondria visualization and tracking. Chem. Sci. 2019, 10, 1994-2000.

[7] Ruoyao Zhang, Yuming Sun, Mianggang Tian, Ge Zhang, Ruiqing Feng, Xuechen Li, Lifang Guo, Xiaoqiang Yu*, Jing Zhi Sun*, and Xiuquan He*. Phospholipid-Biomimetic Fluorescent Mitochondrial Probe with Ultrahigh Selectivity Enables In Situ and High-Fidelity Tissue Imaging. Anal. Chem. 2017, 89, 6575-6582.

[8] Joe H. C. Chau,‡ Ruoyao Zhang,‡ Michelle M. S. Lee, Kristy W. K. Lam, Eric Y. Yu, Jacky W. Y. Lam, Ryan T. K. Kwok,* Ben Zhong Tang*. A ratiometric theranostic system for visualization of ONOO− species and reduction of drug-induced hepatotoxicity. Biomater. Sci. 2022, 10, 1083-1089.

[9] Chao Chen†, Ruoyao Zhang†, Jianyu Zhang†, Yufan Zhang, Haoke Zhang, Zaiyu Wang, Xiaolin Huang, Sijie Chen, Ryan T. K. Kwok, Jacky W. Y. Lam, Dan Ding,* Ben Zhong Tang*. Taming Reactive Oxygen Species: Mitochondria-Targeting Aggregation-Induced Emission Luminogen for Neuron Protection via Photosensitization-Triggered Autophagy. CCS Chem. 2021, 3, 2791-2799.

[10] Xiaolin Huang,# Ruoyao Zhang,# Chao Chen, Ryan T. K. Kwok, and Ben Zhong Tang*. Wash-free detection and bioimaging by AIEgens. Mater. Chem. Front., 2021, 5, 723-743.

[11] Guangle Niu, ‡ Ruoyao Zhang, ‡ John P. C. Kwong, ‡ Jacky W. Y. Lam, Congping Chen, Jianguo Wang, Yuncong Chen, Xing Feng, Ryan T. K. Kwok, Herman H.-Y. Sung, Ian D. Williams, Mark R. J. Elsegood, Jianan Qu, Chao Ma, Kam Sing Wong, Xiaoqiang Yu,* and Ben Zhong Tang*. Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration. Chem. Mater. 2018, 30, 4778-4787.

[12] Lifang Guo,‡ Ruoyao Zhang,‡ Yuming Sun, Minggang Tian, Ge Zhang, Ruiqing Feng, Xuechen Li, Xiaoqiang Yu* and Xiuquan He*. Styrylpyridine salts-based red emissive two-photon turn-on probe for imaging the plasma membrane in living cells and tissues. Analyst 2016, 141, 3228-3232.

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2. 于晓强、张若瑶、孙渝明、张革，一种含十八碳烷基链的免洗且快速靶向线粒体的荧光探针及其应用, ZL20161 1115247.3

2014.11 "Creative Youth" national entrepreneurship contest the Ninth "Challenge Cup" College Students' Entrepreneurship Program, gold medal