李航

学科 : 生物医学工程

方向 :高灵敏质谱分析方法及临床应用

电子邮件 :hang.li@bit.edu.cn

办公地址 :北京市海淀区中关村南大街5号北京理工大学7号楼402

个人简历

李航,北京理工大学特别副研究员、助理教授、硕士生导师,博士毕业于美国乔治华盛顿大学,师从美国国家发明家科学院院士Akos Vertes教授,主要研究领域包括基于微流控技术的质谱超灵敏检测方法、单细胞蛋白质组学与代谢组学、以及质谱分析的临床应用。近年来,以第一/共同通讯作者在Angewandte Chemie International Edition、Analytical Chemistry等国际知名期刊发表SCI论文十余篇,著述专著一章,授权发明专利一项。作为项目负责人和主要参与者,主持国家自然科学基金青年项目,参与美国国家自然科学基金和国防高级研究计划局(DARPA)等资助的多个项目。曾获得美国质谱协会Asilomar会议和质谱医药领域会议的青年科研工作者奖等。

教育培训经历

2010.08-2016.05,乔治华盛顿大学(美国),化学系,博士

2006.09-2010.07,北京科技大学,材料科学与工程系,学士

工作经历

2022.08-至今,北京理工大学,医学技术学院,特别副研究员/助理教授

2017.03-2022.07,国家蛋白质科学中心(北京),助理研究员

2016.06-2017.02,乔治华盛顿大学(美国),化学系,博士后研究员

学术任职

担任Analytical Chemistry, International Journal of Mass Spectrometry等期刊审稿人

研究领域

高灵敏质谱分析方法

微量样本/单细胞蛋白质组学与代谢组学

生物质谱的临床应用

讲授课程

临床色谱质谱学

教材及专著

1. Hang Li, Brain K. Smith, Bindesh Shrestha, Laszlo Márk, and Akos Vertes*, “Automated Cell-By-Cell Tissue Imaging and Single Cell Analysis for Targeted Morphologies by Laser Ablation Electrospray Ionization Mass Spectrometry”, in: Mass Spectrometry Imaging of Small Molecules, Methods in Molecular Biology, Vol.: 1203, He Lin (ed), Springer, 2015, 117-127. ISBN-13: 978-1-4939-1356-5. (Book Chapter)

参与项目

1. 国家蛋白质科学中心(北京)主体设施技术创新开放共享课题(2021-NCPSB-004),基于流式的微孔芯片单细胞高通量分选新方法,2021.07-2022.06,共同主持,50万元

2. 国家自然科学基金青年项目(21904008),基于微孔芯片的高灵敏度肿瘤干细胞蛋白-代谢多组学分析新方法,2020.01-2022.12,主持,25万元

3. 美国国防高等研究项目(DAPRA),W911NF-14-2-0020,New Tools for Comparative Systems Biology of Threat Agent Action Mechanisms,2014.01-2018.12,主要参与人

4. 美国国家自然科学基金项目(NSF),CHE-1152302, Single Cell and Subcellular Analysis by Laser Ablation Electrospray Ionization Mass Spectrometry,2012.04-2015.03,主要参与人

5. 美国能源部基金项目(DOE),DE-FG02-01ER15129,Nanostructured Substrates and Imaging Applications of Soft Laser Desorption Ionization, 2010.09-2015.08,主要参与人

SCI Journal paper

1. Baoying Zhang, Hang Li, Linlin Kong, Ningli Yang, Shengjie Yang, Lu Qi, Tong Liu, Xinghe Wang, and Weijie Qin, Tandem Enrichment of Serum Exosomes and Exosomal RNA with Titanium Dioxide, Journal of Chromatography A, 2023, 1693: 463882-463882.

2. Hongxian Zhao, Yongle Chen, Hang Li*, Yangjun Zhang, Wanjun Zhang, and Weijie Qin*, An angled-shape tip-based strategy for highly sensitive proteomic profiling of a low number of cells, Analytical Methods, 2023, 15, 1215-1222.

3. Wenhui Ma, Hang Li, Yujie Wang, Qi Liu, Weijie Qin, Jiayu Liu*, Huan Cheng*, and Wanjun Zhang*. Highly efficient TiO2-based one-step strategy for micro volume plasma-derived extracellular vesicles isolation and multiomics sample preparation. International Journal of Mass Spectrometry, 2023, 483: 116971.

4. Miaomiao Zhang, Tong Liu, Zhuokun Du, Hang Li*, and Weijie Qin*. A new integrated method for tissue extracellular vesicle enrichment and proteome profiling. RSC Advances, 2022, 12(51): 33409–33418.

5. Yuanyuan Li, Hang Li*, Yuping Xie, Shuo Chen, Ritian Qin, Hangyan Dong, Yongliang Yu*, Jianhuan Wang, Xiaohong Qian, and Weijie Qin*, An Integrated Strategy for Mass Spectrometry-Based Multiomics Analysis of Single Cells, Analytical Chemistry, 2021, 93, 14059-14067. (Supplementary Cover)

6. Fulin Guan, Xiaochao Xiang, Yuping Xie, Hang Li*, Wanjun Zhang*, Yang Shu*, Jianhua Wang*, and Weijie Qin, Simultaneous Metabolomics and Proteomics Analysis of Plasma-derived Extracellular Vesicles, Analytical Methods, 2021, 13, 1930-1938.

7. Xiaochao Xiang, Fulin Guan, Fenglong Jiao, Hang Li*, Wanjun Zhang*, Yangjun Zhang*, and Weijie Qin, A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles, Analytical Methods, 2021, 13, 1591-1600.

8. Lili Hu, Chuangui Zhou, Hang Li, Mei Zhang, and Wei Xu*, Instantaneous Response of Bacteria to External Stimuli Monitored by Syringe Spray Mass Spectrometry, Analytical Chemistry, 2018, 90:11417-11422.

9. Xinyu Si, Lili Hu, Wei Xu, Hang Li* and Cuiping Li*, A dual-source miniature mass spectrometer with improved sensitivity, International Journal of Mass Spectrometry, 2017, 423: 15-19.

10. Hang Li, and Akos Vertes*, Solvent Gradient Electrospray for Laser Ablation Electrospray Ionization Mass Spectrometry, Analyst, 2017, 142: 2921-2927.

11. Hang Li, Pranav Balan, and Akos Vertes*, Molecular Imaging of Growth, Metabolism, and Antibiotic Inhibition in Bacterial Colonies by Laser Ablation Electrospray Ionization Mass Spectrometry, Angewandte Chemie International Edition, 2016, 55: 15035-15039. (Inside Back Cover)

12. Hang Li#, Emmeline Ha#, Robert P. Donaldson, Aleksandar M. Jeremic and Akos Vertes*, Rapid Assessment of Human Amylin Aggregation and its Inhibition by Copper(II) Ions Revealed by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation, Analytical Chemistry, 2015, 87: 9829-9837.

13. Hang Li, Brain K. Smith, Laszlo Márk, Peter Nemes, Javad Nazarian and Akos Vertes*, Ambient Molecular Imaging by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation, International Journal of Mass Spectrometry, 2015, 375: 681-689.

EI Journal paper

中文论文

专利

1. 基于微孔阵列芯片的微量样本代谢组、蛋白质组和磷酸化蛋白质组多组学分析方法,中国,ZL202110388038.0,秦伟捷,李航,李圆圆(授权)

所获奖励/荣誉