赵洪友 副研究员(助理教授)

学科 : 生物医学工程

方向 :生物医学光子学

电子邮件 :zhaohy@bit.edu.cn

办公地址 :北京市海淀区中关村南大街5号北京理工大学医学技术学院

个人简历

赵洪友博士长期从事新型医用光敏药物的研发及临床转化,水依赖可逆光酸疗法的抗肿瘤机制研究,光治疗创伤后应激障碍的机制研究以及可穿戴设备的研制。参与研发的化学1.1类新型光敏药物海默泊芬(HMME)已被国家食品药品监督管理局批准用于临床(国药证字H20120076);参与研发的“倍频Nd:YV04激光光动力治疗仪” 已获国家食品药品监督管理局三类医疗器械认证(国食药监械(准)字2013第3240155号),光学相干成像仪已获北京食品药品监督管理局二类医疗器械认证(京食药监械(准)字2014第2241232号)。近五年以第一/通讯作者在Advanced Science,Biosensors and Bioelectronics,Advanced Healthcare Materials等杂志发表文章二十余篇,主持/参与国家级省部级课题多项。

教育培训经历

2011. 09-2014. 07 解放军总医院 激光医学 博士研究生

2008. 09-2011. 07 华南师范大学 生物医学光子学 硕士研究生

2004. 09-2008. 07 内蒙古大学 生物学 本科

工作经历

2020.01-现在 北京理工大学,医学技术学院, 特别副研究员

2016.09-2019. 03 美国路易斯安那州州立大学,癌症研究中心 博士后

2014.08-2016. 08 美国南阿拉巴马大学,米切尔癌症研究中 博士后

学术任职

中华医学会激光医学分会委员;北京医学会激光医学分会委员;中国光学光电子行业协会激光应用分会青年委员。同时还担任J. Photochem. and Photobio. B, Photodiagnosis Photodyn. Ther.等多个国际学术期刊审稿人。

研究领域

水依赖可逆光酸治疗肿瘤的机制研究

新型光敏药物的研发以及临床前生物功能评价

光治疗创伤后应激障碍的机制研究与可穿戴设备研发

讲授课程

为本科生讲授《细胞生物学》课程

为研究生讲授《生物医学光子学与应用》课程

教材及专著

参与项目

[1] 国家自然科学基金委员会, 重大项目, T2293753, 光动力治疗量效关系及诊疗一体化研究,2023-01至2027-12, 100万元, 在研, 参与

[2] 公司委托技术开发任务,横向项目,201925141023,KAE新药用于光动力治疗CIN临床前药效学评测研究,2020-01至2024-06,147.126万元,在研,主持

[3] 武汉光电国家研究中心开放基金,省部级课题,2020WNLOKF026,光治疗创伤后应激障碍的基础研究及其机制探索,2021-01至2023-12,12万元,结题,主持

[4] 青年教师学术启动计划,学校项目,1870011182003,LED治疗阿尔兹海默症的量效关系和机制研究,2020-01至2023-12,40万元,在研,主持

[5] 国家自然科学基金委员会, 面上项目,61475194,光动力疗法对活化T细胞行为调控及效应机制研究,2015-01至2018-12, 72万元,参与

[6] 国家自然科学基金委员会, 面上项目,61308117,线粒体靶向竹红菌素光动力治疗脉络膜新生血管的实验研究,2013-01至2016-12,66万元,参与

SCI Journal paper

[1] Zhao Xue, Wenxin Chou, Yixuan Xu, ZiYi Cheng, Xuechun Ren, Tianzhen Sun, Wenbin Tong, Yang Xie, Nuohan Zhang, Ying Gu, Yongtian Wang, Xing Sheng, Hongyou Zhao* Jian Yang* He Ding*. Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds. Biosensors and Bioelectronics. 2024, 261, 116467. (中科院1区Top期刊)

[2] Shiyang Liu, Tianzhen Sun, Wenxin Chou, Chen Gao, Hongyou Zhao*, Yuxia Zhao*. Molecular engineering design of twisted-backbone pure Type-I organic photosensitizers for hypoxic photodynamic therapy. Eur. J. Med. Chem. 2024, 273,116503. (中科院1区Top期刊)

[3] Lin Kang, Tianzhen Sun, Shiyang Liu, Hongyou Zhao*, Yuxia Zhao*. Porphyrin derivative with binary properties of photodynamic therapy and water-dependent reversible photoacidity therapy for treating hypoxic tumor. Advanced Healthcare Materials. 2024, 2303856.(中科院1区Top期刊)

[4] Shiyang Liu, Tianzhen Sun, Wenxin Chou, Hongyou Zhao*, Yuxia Zhao*. A design strategy of pure Type-I thiadiazolo[3,4-g] quinoxaline-based photosensitizers for photodynamic therapy. Eur. J. Med. Chem. 2024, 265,116059. (中科院1区Top期刊)

[5] Tianzhen Sun, Lin Kang, Hongyou Zhao*, Yuxia Zhao*, Ying Gu*. Photoacid Generators for Biomedical Applications. Advanced Science. 2023, 2302875. (中科院1区Top期刊)

[6] Wenxin Chou, Tianzhen Sun, Nian Peng, Zixuan Wang, Defu Chen, Haixia Qiu and Hongyou Zhao*. Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies. Pharmaceutics 2023, 15, 2617. (中科院2区期刊)

[7] Kerui Li, Qijia Wu, Shiyu Feng*, Hongyou Zhao*, Wei Jin, Haixia Qiu, Ying Gu, Defu Chen*. In situ detection of human glioma based on tissue optical properties using diffuse reflectance spectroscopy. J Biophotonics 2023, jbio.202300195.

[8] Hongyou Zhao*, Yi Li, Ting Luo, Wenxin Chou, Tianzhen Sun, Haolin Liu, Haixia Qiu, Dan Zhu, Defu Chen*, Ying Gu* Preventing Post-Traumatic Stress Disorder (PTSD) in Rats with Pulsed 810 nm Laser Transcranial Phototherapy. Translational Psychiatry 2023. 13:281.(中科院1区Top期刊)

[9] Lin Kang, Shiyang Liu, Xing Huang, Diqin Zhang, Hongyou Zhao*, Yuxia Zhao* Cyclopentylmalononitrile dye as an efficient photosensitizer for combined photodynamic and water-dependent reversible photoacidity therapy. J Photoch. Photobio. A 2023.441:114701.

[10] Lin Kang, Hongyou Zhao*, Shiyang Liu, Yupeng Liu, Yidi Liu, Defu Chen, Haixia Qiu, Jian Yang, Ying Gu, Yuxia Zhao* A water-dependent reversible photoacidity strategy for cancer treatment. Eur. J. Med. Chem. 2022. 242:114669. (中科院1区Top期刊)

[11] Hongyou Zhao*, Haolin Liu, Lin Kang, Tianzhen Sun, Yidi Liu, Defu Chen and Ying Gu*. In vitro and in vivo evaluation of a chlorin-based photosensitizer KAE® for cancer treatment. Photodiagnosis Photodyn Ther. 2022. 38: 102759.

[12] Hongyou Zhao, Tengda Ji, Tianzhen Sun, Haolin Liu, Yidi Liu, Haixia Qiu and Ying Gu* et al. “Comparative study on photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo” J. Innov. Opt. Heal. Sci. 2022. 15: 2250010.

[13] Hongyou Zhao, Yi Bin, Zhipin Liang, Adam I. Riker, and Yaguang Xi*. “Cyclin G2, a novel target of sulindac to inhibit cell cycle progression in colorectal cancer” Genes & Diseases. 2021. 8: 320-330. (中科院2区期刊)

[14] Li-Peng Zhang, Xianqiang Li, Hongyou Zhao*, Lin Kang Tianlong Liu and Yuxia Zhao* et al. “Ultra-high photoactive thiadiazolo [3,4-g] quinoxaline nanoparticles with active-targeting capability for deep photodynamic therapy” J. Mater. Chem. B. 2021. 9: 8330–8340.

EI Journal paper

[1] Hongyou Zhao, Bin Yi, Ruixia Ma and Yaguang Xi. MiR-182 is involved in sulindac anticancer activity in colon cancer. 2017 AACR Annual Meeting: Research Propelling Cancer Prevention and Cures. Washington, D.C

[2] Hongyou Zhao, Bin Yi, Hong Chang, Zhipin Liang, Ruixia Ma and Yaguang Xi. Sulindac inhibition of colon tumor cell growth through miR-182/FOXO3a/CyclinG2 signaling. 2016 AACR Precision Medicine Series: Cancer Cell Cycle-Tumor Progression and Therapeutic Response. Orlando FL.

[3] Hongyou Zhao, Jie Ren, Rong Yin, Ying Wang, Ying Gu. The mechanism of apoptosis induced by photodynamic therapy. 2012 SPIE-Photonics Asia Meeting. Beijing.

中文论文

[1] 侴雯馨,孙天真,顾瑛*,赵洪友* 光动力疗法的抗肿瘤免疫效应研究进展,解放军医学杂志,2024,49,6 ISSN 0577-7402

[2] 孙天真,李科锐,邱海霞,曾晶,顾瑛*,赵洪友* 肿瘤光动力治疗中乏氧问题解决策略的研究进展,中国激光医学杂志, 2022,31:213-221

[3] 刘浩林,邱海霞,曾晶,赵洪友*,顾瑛* 新型二氢卟吩类光敏剂KAE介导的光动力疗法对HeLa细胞的杀伤作用,中国激光医学杂志,2021,30:301-305



专利

[1] 一种具有疗效监测功能的头戴式创伤后应激障碍光疗仪,发明人:赵洪友,李科锐,侴温馨,陈德福,孙天真,2023-04-19,申请号:202310422002.9

[2] 一种基于卟吩结构的光敏剂、制备和应用,发明人:赵榆霞,康琳,赵洪友,孙天真,2022-11-15,专利号:ZL202211278279.0

[3] 二氢卟酚e6三葡甲胺盐在光动力治疗宫颈癌及癌前病变中的应用,发明人:顾瑛,庞玉华,吴思丹,赵洪友,宋治国,2021-08-27,专利号:CN113304263A

[4] 布鲁氏杆菌的检测试剂盒与检测方法,发明人:姚杰,赵洪友,程诚,2021-02-05,专利号:CN112322764A

[5] 叶酸代谢相关分子标志物基因突变的检测试剂盒与检测方法,发明人:姚杰,赵洪友,程诚,2021-03-19,专利号:CN112522375A

[6] 一种基于积分球效应的光动力治疗器械, 发明人:顾瑛,孙圣坤,谭一舟,邱海霞,陈德福,赵洪友,曾晶,王颖,2020-11-8, 专利号:ZL202011295644.X.

[7] 一种新型光动力治疗器械,发明人:邱海霞,顾瑛,孟元光,谭一舟,陈德福,赵洪友,王颖,曾晶,2020-10-20, 专利号:ZL202011295666.6.

[8] 用于脑癌术中引导的光谱诊断系统及其工作方法,发明人:陈德福; 李科锐; 彭念; 顾瑛; 邱海霞; 赵洪友,2022-02-16, 中国, CN202210140944.3

所获奖励/荣誉

[1] 肖以磊,姚杰,左小青,赵洪友,邢晓辉,李中辰,刘超,李孟友。基于CRISPR技术开发的基因检测系统-可移动的分子精准检测实验室, 中国山东博士后创新创业大赛组委会, 省部二等奖, 2023.08