水依赖可逆光酸治疗肿瘤的机制研究

新型光敏药物的研发以及临床前生物功能评价

光治疗创伤后应激障碍的机制研究与可穿戴设备研发

为本科生讲授《细胞生物学》课程

为研究生讲授《生物医学光子学与应用》课程

[1] 国家自然科学基金委员会, 重大项目, T2293753, 光动力治疗量效关系及诊疗一体化研究，2023-01至2027-12, 100万元, 在研, 参与

[2] 公司委托技术开发任务，横向项目，201925141023，KAE新药用于光动力治疗CIN临床前药效学评测研究，2020-01至2024-06，147.126万元，在研，主持

[3] 武汉光电国家研究中心开放基金，省部级课题，2020WNLOKF026，光治疗创伤后应激障碍的基础研究及其机制探索，2021-01至2023-12，12万元，结题，主持

[4] 青年教师学术启动计划，学校项目，1870011182003，LED治疗阿尔兹海默症的量效关系和机制研究，2020-01至2023-12，40万元，在研，主持

[5] 国家自然科学基金委员会, 面上项目，61475194，光动力疗法对活化T细胞行为调控及效应机制研究，2015-01至2018-12, 72万元，参与

[6] 国家自然科学基金委员会, 面上项目，61308117，线粒体靶向竹红菌素光动力治疗脉络膜新生血管的实验研究，2013-01至2016-12，66万元，参与

[1] Zhao Xue, Wenxin Chou, Yixuan Xu, ZiYi Cheng, Xuechun Ren, Tianzhen Sun, Wenbin Tong, Yang Xie, Nuohan Zhang, Ying Gu, Yongtian Wang, Xing Sheng, Hongyou Zhao* Jian Yang* He Ding*. Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds. Biosensors and Bioelectronics. 2024, 261, 116467. （中科院1区Top期刊）

[2] Shiyang Liu, Tianzhen Sun, Wenxin Chou, Chen Gao, Hongyou Zhao*, Yuxia Zhao*. Molecular engineering design of twisted-backbone pure Type-I organic photosensitizers for hypoxic photodynamic therapy. Eur. J. Med. Chem. 2024, 273,116503. （中科院1区Top期刊）

[3] Lin Kang, Tianzhen Sun, Shiyang Liu, Hongyou Zhao*, Yuxia Zhao*. Porphyrin derivative with binary properties of photodynamic therapy and water-dependent reversible photoacidity therapy for treating hypoxic tumor. Advanced Healthcare Materials. 2024, 2303856.（中科院1区Top期刊）

[4] Shiyang Liu, Tianzhen Sun, Wenxin Chou, Hongyou Zhao*, Yuxia Zhao*. A design strategy of pure Type-I thiadiazolo[3,4-g] quinoxaline-based photosensitizers for photodynamic therapy. Eur. J. Med. Chem. 2024, 265,116059. （中科院1区Top期刊）

[5] Tianzhen Sun, Lin Kang, Hongyou Zhao*, Yuxia Zhao*, Ying Gu*. Photoacid Generators for Biomedical Applications. Advanced Science. 2023, 2302875. （中科院1区Top期刊）

[6] Wenxin Chou, Tianzhen Sun, Nian Peng, Zixuan Wang, Defu Chen, Haixia Qiu and Hongyou Zhao*. Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies. Pharmaceutics 2023, 15, 2617. （中科院2区期刊）

[7] Kerui Li, Qijia Wu, Shiyu Feng*, Hongyou Zhao*, Wei Jin, Haixia Qiu, Ying Gu, Defu Chen*. In situ detection of human glioma based on tissue optical properties using diffuse reflectance spectroscopy. J Biophotonics 2023, jbio.202300195.

[8] Hongyou Zhao*, Yi Li, Ting Luo, Wenxin Chou, Tianzhen Sun, Haolin Liu, Haixia Qiu, Dan Zhu, Defu Chen*, Ying Gu* Preventing Post-Traumatic Stress Disorder (PTSD) in Rats with Pulsed 810 nm Laser Transcranial Phototherapy. Translational Psychiatry 2023. 13:281.（中科院1区Top期刊）

[9] Lin Kang, Shiyang Liu, Xing Huang, Diqin Zhang, Hongyou Zhao*, Yuxia Zhao* Cyclopentylmalononitrile dye as an efficient photosensitizer for combined photodynamic and water-dependent reversible photoacidity therapy. J Photoch. Photobio. A 2023.441:114701.

[10] Lin Kang, Hongyou Zhao*, Shiyang Liu, Yupeng Liu, Yidi Liu, Defu Chen, Haixia Qiu, Jian Yang, Ying Gu, Yuxia Zhao* A water-dependent reversible photoacidity strategy for cancer treatment. Eur. J. Med. Chem. 2022. 242:114669. （中科院1区Top期刊）

[11] Hongyou Zhao*, Haolin Liu, Lin Kang, Tianzhen Sun, Yidi Liu, Defu Chen and Ying Gu*. In vitro and in vivo evaluation of a chlorin-based photosensitizer KAE® for cancer treatment. Photodiagnosis Photodyn Ther. 2022. 38: 102759.

[12] Hongyou Zhao, Tengda Ji, Tianzhen Sun, Haolin Liu, Yidi Liu, Haixia Qiu and Ying Gu* et al. “Comparative study on photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo” J. Innov. Opt. Heal. Sci. 2022. 15: 2250010.

[13] Hongyou Zhao, Yi Bin, Zhipin Liang, Adam I. Riker, and Yaguang Xi*. “Cyclin G2, a novel target of sulindac to inhibit cell cycle progression in colorectal cancer” Genes & Diseases. 2021. 8: 320-330. （中科院2区期刊）

[14] Li-Peng Zhang, Xianqiang Li, Hongyou Zhao*, Lin Kang Tianlong Liu and Yuxia Zhao* et al. “Ultra-high photoactive thiadiazolo [3,4-g] quinoxaline nanoparticles with active-targeting capability for deep photodynamic therapy” J. Mater. Chem. B. 2021. 9: 8330–8340.

[1] Hongyou Zhao, Bin Yi, Ruixia Ma and Yaguang Xi. MiR-182 is involved in sulindac anticancer activity in colon cancer. 2017 AACR Annual Meeting: Research Propelling Cancer Prevention and Cures. Washington, D.C

[2] Hongyou Zhao, Bin Yi, Hong Chang, Zhipin Liang, Ruixia Ma and Yaguang Xi. Sulindac inhibition of colon tumor cell growth through miR-182/FOXO3a/CyclinG2 signaling. 2016 AACR Precision Medicine Series: Cancer Cell Cycle-Tumor Progression and Therapeutic Response. Orlando FL.

[3] Hongyou Zhao, Jie Ren, Rong Yin, Ying Wang, Ying Gu. The mechanism of apoptosis induced by photodynamic therapy. 2012 SPIE-Photonics Asia Meeting. Beijing.

[1] 侴雯馨，孙天真，顾瑛*，赵洪友* 光动力疗法的抗肿瘤免疫效应研究进展，解放军医学杂志，2024，49，6 ISSN 0577-7402

[2] 孙天真，李科锐，邱海霞，曾晶，顾瑛*，赵洪友* 肿瘤光动力治疗中乏氧问题解决策略的研究进展，中国激光医学杂志， 2022，31：213-221

[3] 刘浩林，邱海霞，曾晶，赵洪友*，顾瑛* 新型二氢卟吩类光敏剂KAE介导的光动力疗法对HeLa细胞的杀伤作用，中国激光医学杂志，2021，30：301-305

[1] 一种具有疗效监测功能的头戴式创伤后应激障碍光疗仪，发明人：赵洪友，李科锐，侴温馨，陈德福，孙天真，2023-04-19，申请号：202310422002.9

[2] 一种基于卟吩结构的光敏剂、制备和应用，发明人：赵榆霞，康琳，赵洪友，孙天真，2022-11-15，专利号：ZL202211278279.0

[3] 二氢卟酚e6三葡甲胺盐在光动力治疗宫颈癌及癌前病变中的应用，发明人：顾瑛，庞玉华，吴思丹，赵洪友，宋治国，2021-08-27，专利号：CN113304263A

[4] 布鲁氏杆菌的检测试剂盒与检测方法，发明人：姚杰，赵洪友，程诚，2021-02-05，专利号：CN112322764A

[5] 叶酸代谢相关分子标志物基因突变的检测试剂盒与检测方法，发明人：姚杰，赵洪友，程诚，2021-03-19，专利号：CN112522375A

[6] 一种基于积分球效应的光动力治疗器械, 发明人：顾瑛，孙圣坤，谭一舟，邱海霞，陈德福，赵洪友，曾晶，王颖，2020-11-8, 专利号：ZL202011295644.X.

[7] 一种新型光动力治疗器械，发明人：邱海霞，顾瑛，孟元光，谭一舟，陈德福，赵洪友，王颖，曾晶，2020-10-20, 专利号：ZL202011295666.6.

[8] 用于脑癌术中引导的光谱诊断系统及其工作方法，发明人：陈德福; 李科锐; 彭念; 顾瑛; 邱海霞; 赵洪友，2022-02-16, 中国, CN202210140944.3

[1] 肖以磊，姚杰，左小青，赵洪友，邢晓辉，李中辰，刘超，李孟友。基于CRISPR技术开发的基因检测系统-可移动的分子精准检测实验室, 中国山东博士后创新创业大赛组委会, 省部二等奖, 2023.08