无创光疗指利用不引起人体组织和细胞不可逆损伤强度的光照射人体，通过光对组织和细胞功能的调节作用，达到治疗目的一种物理疗法。其突出特点是无创、效果好、可重复使用及临床适应证广泛。目前，无创光疗已经广泛用于治疗内、外、妇、儿、眼、耳、口腔等几乎所有临床科室的三百五十多种疾病，在促进伤口愈合、缓解疼痛、消退炎症、再生组织及缓解肌肉疲劳等症状中有良好功效。近年来，无创光疗在调节脑功能方面突显潜能，如干预生物节律紊乱、神经退行性疾病、创伤后应激障碍、成瘾等，但其作用机制不清楚。本人主要致力于新型无创光疗光生物效应的机制研究，包括原初光反应机制和级联信号转导，目的在于获得光生物效应的量效规律，以指导临床应用。

• 2012 细胞生物学 研究生课程

• Da Xing, Shengnan Wu. Low-Level Laser Therapy Signaling Pathways. Chapter 47 in Handbook of Photomedicine. 2013. Edited by Michael R. Hamblin, Yingying Hang. https://doi.org/10.1201/b15582.

• 项目名称：线粒体选择性损伤的肿瘤低功率激光疗法机制研究 (S2011040003254) 项目性质及来源：广东省自然科学基金 (博士启动) 起止年度：2011 — 2013；主持
• 项目名称：线粒体选择性损伤的肿瘤低功率激光疗法机制研究 (20114407120002) 项目性质及来源：教育部高等学校博士学科点专项科研基金 (新教师类) 起止年度：2012 — 2014；主持
• 项目名称：高通量低功率激光照射诱导线粒体活性氧产生的机制研究(61308111) 项目性质及来源：国家自然科学基金 (青年基金) 起止年度：2014 — 2016；主持
• 项目名称：基于高通量低功率激光靶向损伤线粒体的肿瘤激光疗法机制研究 项目性质及来源：广州市珠江科技新星专项 起止年度：2014 — 2016；主持
• 项目名称：The Role of FUNDC1 in Mitochondrial Dynamics in Cardiomyocytes (16POST29960011) (FUNDC1在心肌细胞内线粒体形态变化中的作用) 项目性质及来源：American Heart Association Postdoctoral Fellowship Award (美国心脏病学会博士后基金) 起止年度：2016 — 2018；主持
• 项目名称：The Role of the Mitochondria and Endoplasmic Reticulum Contacts in Diabetic Cardiomyopathy (19CDA34760110) (内质网与线粒体的互作在糖尿病心肌病中的作用)项目性质及来源：American Heart Association Career Development Award (美国心脏病学会职业发展基金) 起止年度：2019 — 2022；主持

• 第一作者/通讯作者 • • Wu S*, Zou MH. AMPK, mitochondrial function, and cardiovascular disease. Int. J. Mol. Sci.; 2020,21(14):4987.
• Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, Mao X, Huang K, Xie Z, Zou MH*. Hyperglycemia-driven inhibition of AMP-activated protein kinase 2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo; Circulation; 2019,139(16):1913-36.
• Wu S, Zou MH*. Mitochondria-associated endoplasmic reticulum membranes in the heart; Arch. Biochem. Biophy.; 2018,662:201-12.
• Wu S#, Lu Q#, Wang Q, Ding Y, Ma Z, Mao X, Huang K, Xie Z, Zou MH*. Binding of FUN14 domain containing 1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum membrane maintains mitochondrial dynamics and function in hearts in vivo; Circulation; 2017,136(23):2248-66.
• Wu S, Xing D*. Intracellular signaling cascades following light irradiation; Laser Photonics Rev.; 2014,8(1):115-30.
• Wu S, Zhou F, Wei Y, Chen WR, Chen Q, Xing D*. Cancer phototherapy via selective photoinactivation of respiratory chain oxidase to trigger a fatal superoxide anion burst; Antioxid. Redox Signal.; 2014,20(5)733-46.
• Zhou F#, Wu S#, Yuan Y, Chen WR, Xing D*. Mitochondria-targeting photoacoustic therapy using single-walled carbon nanotubes; Small; 2012,8(10):1543-50.
• Wu S, Xing D*. Mechanism of mitochondrial membrane permeabilization during apoptosis under photofrin-mediated photodynamic therapy; J. Xray Sci. Technol.; 2012,20(3):363-72.
• Zhou F#, Wu S#, Wu B, Chen WR, Xing D*. Mitochondria-targeting single-walled carbon nanotubes for cancer photothermal therapy; Small; 2011,7(19):2727-35.
• Wu S, Zhou F, Zhang Z, Xing D*. Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins; FEBS J.; 2011,278(6):941-54.
• Wu S, Zhou F, Zhang Z, Xing D*. Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy; J. Cell. Physiol.; 2011,226(2):530-41.
• Wu S, Xing D*, Gao X, Chen WR. High fluence low-power laser irradiation induces mitochondrial permeability transition mediated by reactive oxygen species; J. Cell. Physiol.; 2009,218(3):603-11.
• Wu S, Xing D*, Wang F, Chen T, Chen WR. Mechanistic study of apoptosis induced by high-fluence low-power laser irradiation using fluorescence imaging techniques; J. Biomed. Opt.; 2007,12(6), 064015.
• • 挂名
• • Zou MH∗; Wu S. Adenosine Monophosphate-Activated Protein Kinase, Oxidative Stress, and Diabetic Endothelial Dysfunction. Cardiology Discovery; 2021,1(1), 44-57.
• Reddish FN, Miller CL, Deng X, Dong B, Patel AA, Ghane MA, Mosca B, McBean C, Wu S, Solntsev KM, Zhuo Y, Gadda G, Fang N, Cox DN, Mabb AM, Treves S, Zorzato F, Yang JJ. Rapid subcellular calcium responses and dynamics by calcium sensor G-CatchER. iScience; 2021,3;24(3):102129.
• Wang C, Dai X, Wu S, Xu W, Song P, Huang K. FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis. Nat. Commun.; 2021,12(1):2616.
• Sasaki M, North PE, Elsey J, Bubley J, Rao S, Jung Y, Wu S, Zou MH, Pollack, BP, Kumar J, Singh H, Arbiser JL. Propranolol exhibits activity against hemangiomas independent of beta blockade, NPJ Precis. Oncol.; 2019, 3:27.
• Lu Q, Xie Z, Yan C, Ding Y, Ma Z, Wu S, Qiu Y, Cossette SM, Bordas M, Ramchandran R, Zou MH. SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo; Arterioscler. Thromb. Vasc. Biol.; 2018,38(2):373-385.
• Wu L, Pang Y, Qin G, Xi G, Wu S, Wang X, Chen T. Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives; PLoS One; 2017,12(2):e0171840.
• Wang Q, Wu S, Zhu H, Ding Y, Dai X, Ouyang C, Han YM, Xie Z, Zou MH. Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L; Autophagy; 2017,13(2):404-422.
• Wang Q, Zhang M, Torres G, Wu S, Ouyang C, Xie Z, Zou MH. Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission; Diabetes; 2017,66(1):193-205.
• Cai Z, Ding Y, Zhang M, Lu Q, Wu S, Zhu H, Song P, Zou MH. Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo; Circ. Res.; 2016,119(3):422-33.
• Zhang Z, Liu L, Wu S, Xing D. Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation-induced apoptosis; FASEB J.; 2016,30(1):466-76.
• Lu C, Zhou F, Wu S, Liu L, Xing D. Phototherapy-Induced Antitumor Immunity: Long-Term Tumor Suppression Effects via Photoinactivation of Respiratory Chain Oxidase-Triggered Superoxide Anion Burst; Antioxid. Redox Signal.; 2016,24(5):249-62.
• Qin G, Wu L, Liu H, Pang Y, Zhao C, Wu S, Wang X, Chen T. Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells; Exp. Cell Res.; 2015,336(2):308-17.
• Qin G, Zhao C, Zhang L, Liu H, Quan Y, Chai L, Wu S, Wang X, Chen T. Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells; Apoptosis; 2015,20(8):1072-86.
• Zhao C, Qin G, Gao W, Chen J, Liu H, Xi G, Li T, Wu S, Chen T. Potent proapoptotic actions of dihydroartemisinin in gemcitabine-resistant A549 cells; Cell. Signal.; 2014,26(10):2223-33.
• Zhou F, Wu S, Song S, Chen WR, Resasco DE, Xing D. Antitumor immunologically modified carbon nanotubes for photothermal therapy; Biomaterials; 2012,33(11):3235-42.
• Zhang H, Wu S, Xing D. Inhibition of Aβ(25-35)-induced cell apoptosis by low-power-laser-irradiation (LPLI) through promoting Akt-dependent YAP cytoplasmic translocation; Cell. Signal.; 2012,24(1):224-32.
• Zhang H, Wu S, Xing D. YAP accelerates Aβ(25-35)-induced apoptosis through upregulation of Bax expression by interaction with p73; Apoptosis; 2011,16(8):808-21.
• Meng C, Wu S, Xing D. Real-time fluorescence imaging of sirt1 cytosolic translocation under the treatment of growth factor deprivation; J. Innov. Opt. Health Sci. 2011,4(02), 133-41.
• Sun X, Wu S, Xing D. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation; FEBS J.; 2010,277(22):4789-802.
• Huang L, Wu S, Xing D. High fluence low-power laser irradiation induces apoptosis via inactivation of Akt/GSK3β signaling pathway; J. Cell. Physiol.; 2011,226(3):588-601.
• Chu J, Wu S, Xing D. Survivin mediates self-protection through ROS/cdc25c/CDK1 signaling pathway during tumor cell apoptosis induced by high fluence low-power laser irradiation; Cancer Lett.; 2010,297(2):207-19.
• Zhou F, Xing D, Wu B, Wu S, Ou Z, Chen WR. New insights of transmembranal mechanism and subcellular localization of noncovalently modified single-walled carbon nanotubes; Nano Lett.; 2010,10(5):1677-81.
• Zhou F, Xing D, Wu S, Chen WR. Intravital imaging of tumor apoptosis with FRET probes during tumor therapy; Mol. Imaging Biol.; 2010,12(1):63-70.
• Zhang L, Xing D, Gao X, Wu S. Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway; J. Cell. Physiol.; 2009,219(3):553-62.

• Shengnan Wu, Da Xing*. The Study on the Mechanism of Cell Apoptosis Induced by High Fluence Low-Power Laser Irradiation. IEEE 2007 IEEE/ICME International Conference on Complex Medical Engineering - Beijing, China. doi:10.1109/iccme.2007.4381890.
• Shengnan Wu, Da Xing*, Lei Huang, Xuegang Sun, Jiru Chu. High Fluence Low-Power Laser Irradiation induced Bax activation. in Conference on Lasers and Electro-Optics/Pacific Rim 2009, (Optical Society of America, 2009), paper ThF2_5.
• Shengnan Wu, Da Xing*. Characteristics and Mechanism of Cell Apoptosis Induced by High Fluence Low-Power Laser Irradiation Biophotonics and Immune Responses III. Proc. of SPIE Vol. 6857, 68570B, (2008). doi: 10.1117/12.762118.
• Shengnan Wu*, Lei Huang, Xuegang Sun, Jiru Chu. Measuring Dynamics of Caspase-9 Activity in Living Cells Using FRET Technique during Apoptosis Induced by High Fluence Low-Power Laser Irradiation. Seventh International Conference on Photonics and Imaging in Biology and Medicine, Proc. of SPIE Vol. 7280, 728023 (2009). doi: 10.1117/12.822153.
• Shengnan Wu*, Lei Huang, Xuegang Sun, Jiru Chu. Mitochondrial Injury Caused by Reactive Oxygen Species Generation under High Fluence Low-Power Laser Irradiation Treatment. Biophotonics and Immune Responses IV, edited by Wei R. Chen, Proc. of SPIE Vol. 7178, 71780L (2009) doi: 10.1117/12.808113.
• Shengnan Wu, Da Xing*. Mitochondrial Signaling Pathway Involved in Cell Apoptosis Induced by High Fluence Low-Power Laser Irradiation. Mechanisms for Low-Light Therapy VI, Proc. of SPIE Vol. 7887, 78870C (2011). doi: 10.1117/12.874283.
• Shengnan Wu, Feifan Zhou, Da Xing*. Low-power laser irradiation enhance macrophage phagocytic capacity through Src activation. Biophotonics and Immune Responses VII, edited by Wei R. Chen, Proc. of SPIE Vol. 8224, 82240N (2012) doi: 10.1117/12.906599.
• Shengnan Wu, Feifan Zhou, Da Xing*. Mechanism study on mitochondrial fragmentation under oxidative stress caused by high fluence low-power laser irradiation. Mechanisms for Low-Light Therapy VII, Proc. of SPIE Vol. 8211, 82110K (2012). doi: 10.1117/12.905332.
• Zhenzhen Zhang, Shengnan Wu*, Jie Feng. Dynamin-Related Protein 1 Translocates from the Cytosol to Mitochondria during UV-Induced Apoptosis. The 9th International Conference on Photonics and Imaging in Biology and Medicine IOP Publishing Journal of Physics: Conference Series 277 (2011) 012051 doi:10.1088/1742-6596/277/1/012051.
• Heng Zhang, Shengnan Wu*. Yes-Associated Protein (YAP) Promotes the Nuclear Import of p73. The 9th International Conference on Photonics and Imaging in Biology and Medicine IOP Publishing Journal of Physics: Conference Series 277 (2011) 012050 doi:10.1088/1742-6596/277/1/012050
• Heng Zhang, Shengnan Wu*. Low-Power Laser Irradiation Inhibits Amyloid Beta-Induced Cell Apoptosis. Mechanisms for Low-Light Therapy VI, Proc. of SPIE Vol. 7887, 78870Q (2011) doi: 10.1117/12.874156.
• Zhenzhen Zhang, Jie Feng, Shengnan Wu*. Roles of Dynamin-Related Protein 1 in the Regulation of Mitochondrial Fission and Apoptosis in Response to UV Stimuli. Biophotonics and Immune Responses VI, edited by Wei R. Chen, Proc. of SPIE Vol. 790079000G (2011) doi: 10.1117/12.874292.

• 吴胜男*, 周非凡. PDT诱导凋亡和坏死的机制研究. 华南师范大学学报(自然科学版), 2012, 44(2).
• 吴胜男, 邢达*. 利用荧光共振能量转移技术监测高通量低能量激光诱导细胞凋亡过程中caspase-3活性的动态变化. 激光生物学报, 2007, 16(4).
• 吴胜男, 邢达*. 高通量低功率激光照射诱导肿瘤细胞凋亡的分子机制研究, 激光生物学报2012, 21(1).
• 冯杰，吴胜男*. 低功率激光照射诱导的细胞外调节蛋白激酶的激活促进一氧化氮的产生,激光生物学报, 2012, 21(4).

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• 2014 Guangzhou Pearl River Science and Technology Rising Star
• 2016 American Heart Association (AHA) Postdoctoral Fellowship Award
• 2019 American Heart Association (AHA) Career Development Award
• 2021 National Overseas Excellent Youth